Chih‐Hsiang Tu

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1

Yi‐Hui Peng, Shau‐Hua Ueng, Chen‐Tso Tseng et al. · Journal of Medicinal Chemistry · 2015 · 135 citations · Full text

Bioorganic Chemistry, Aldo-keto Reductase, Imidazoleisoindole Derivatives +17

Structural basis of HLX10 PD-1 receptor recognition, a promising anti-PD-1 antibody clinical candidate for cancer immunotherapy

Hassan Issafras, Shilong Fan, Chi-Ling Tseng et al. · PLoS ONE · 2021 · 47 citations · Full text

Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)

Chih‐Hsiang Tu, Wen‐Hsing Lin, Yi‐Hui Peng et al. · Journal of Medicinal Chemistry · 2016 · 31 citations · Full text

Drug Target, Molecular Biology, Conformational Switching +26

Correlations between membrane immersion depth, orientation, and salt-resistance of tryptophan-rich antimicrobial peptides

Huiyuan Yu, Bak‐Sau Yip, Chih‐Hsiang Tu et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2013 · 22 citations

Membrane Immersion Depth, Biochemistry, Peptide Library +7

Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants

Tsung-Sheng Wu, Wen‐Hsing Lin, Hui‐Jen Tsai et al. · Journal of Medicinal Chemistry · 2019 · 13 citations · Full text

Drug Target, Gastrointestinal Pharmacology, Molecular Biology +19