Harinder S. Hundal

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

Darren A.E. Cross, Dario R. Alessi, Jackie R. Vandenheede et al. · Biochemical Journal · 1994 · 481 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism

Darren Powell, Éric Hajduch, Gursant Kular et al. · Molecular and Cellular Biology · 2003 · 352 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

Éric Hajduch, Dario R. Alessi, Brian A. Hemmings et al. · Diabetes · 1998 · 333 citations

Life Sciences, Biochemistry, Molecular Biology +17

Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

Darren Powell, Sophie Turban, Alexander Gray et al. · Biochemical Journal · 2004 · 258 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.

Harinder S. Hundal, André Marette, Yasuhide Mitsumoto et al. · Journal of Biological Chemistry · 1992 · 256 citations · Full text

Life Sciences, Biochemistry, Physiology +13