José Henrique Ledo

Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Julia R. Clarke, Natalia M. Lyra e Silva, Cláudia P. Figueiredo et al. · EMBO Molecular Medicine · 2015 · 214 citations · Full text

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

Cláudia P. Figueiredo, Jason Clarke, José Henrique Ledo et al. · Journal of Neuroscience · 2013 · 184 citations · Full text

Neuropsychology, Persistent Impairment Induced, Synaptic Transmission +25

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice

José Henrique Ledo, Estefania P. Azevedo, Danielle Beckman et al. · Journal of Neuroscience · 2016 · 134 citations · Full text

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Helen M. Melo, Gisele da S. Seixas da Silva, Marcella Ramos Sant’Ana et al. · Cell Reports · 2020 · 125 citations · Full text

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Jordano Brito‐Moreira, Mychael V. Lourenco, Maurício M. Oliveira et al. · Journal of Biological Chemistry · 2017 · 85 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Medicine +8