Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

Bret R. Williams, Vineet R. Prabhu, Karen E. Hunter, +4

Science

CytogeneticsGeneticsCell ProliferationEpigeneticsAneuploidy Affects Proliferation +15

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

Jacob Falck, John H.J. Petrini, Bret R. Williams, +2

Nature Genetics

ChromatinGenome InstabilityChromosome DynamicsCell RegulationChromatin Remodeling +8

Identification of Aneuploidy-Selective Antiproliferation Compounds

Yun‐Chi Tang, Bret R. Williams, Jake J. Siegel, +1

Cell

MedicineAneuploidy-selective Antiproliferation CompoundsAnti-cancer AgentPharmacologyDerivative (Chemistry) +1

Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis

Richard S. Maser, Olga K. Mirzoeva, Julie Wells, +5

Molecular and Cellular Biology

ChromatinGenome InstabilityTranscriptional RegulationCell RegulationMre11 Complex +13

A Murine Model of Nijmegen Breakage Syndrome

Bret R. Williams, Olga K. Mirzoeva, William F. Morgan, +2

Current Biology

Genetic DisorderPathogenesisMurine ModelPathologyNeuropathology +2

Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice

Jan-Willem F Theunissen, Mark I. Kaplan, Patricia A. Hunt, +4

Molecular Cell

Lymphoid NeoplasiaGenome InstabilityCheckpoint FailurePathologyCell Death +5

Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia

Andreas Varkaris, Ermira Pazolli, Hakan Günaydin, +49

Cancer Discovery

Thoughts on Aneuploidy

Eduardo M. Torres, Bret R. Williams, Yaqin Tang, +1

Cold Spring Harbor Symposia on Quantitative Biology

Aneuploidy Stress ResponseChromatinGenome InstabilityAneuploid CellsCytogenetics +12

Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors

Alexander M. Taylor, Bret R. Williams, Fabrizio Giordanetto, +34

Journal of Medicinal Chemistry

Artemis and Nonhomologous End Joining-Independent Influence of DNA-Dependent Protein Kinase Catalytic Subunit on Chromosome Stability

Travis H. Stracker, Bret R. Williams, Ludovic Deriano, +4

Molecular and Cellular Biology

Atm DeficiencyChromosome StabilityGeneticsMolecular BiologyCell Death +14