Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Olivier Govaere, Simon Cockell, Dina Tiniakos, +26

Science Translational Medicine

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Christoph Muus, Malte D. Luecken, Gökcen Eraslan, +98

Inflammatory Lung DiseaseLung InflammationImmunologyViral PathogenesisPathology +14

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Urszula Cytlak, Anastasia Resteu, Sarah Pagan, +15

Immunity

A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells

Joseph Collin, Rachel Queen, Darin Zerti, +20

The Ocular Surface

Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface

Joseph Collin, Rachel Queen, Darin Zerti, +10

The Ocular Surface

Blood and immune development in human fetal bone marrow and Down syndrome

Laura Jardine, Simone Webb, Issac Goh, +61

Nature

Down SyndromeDevelopmental BiologyAutoimmune DiseaseImmune DevelopmentBone Marrow Failure +10

Deconstructing Retinal Organoids: Single Cell RNA-Seq Reveals the Cellular Components of Human Pluripotent Stem Cell-Derived Retina

Joseph Collin, Rachel Queen, Darin Zerti, +5

Stem Cells

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Carla Mellough, Joseph Collin, Rachel Queen, +7

Stem Cells Translational Medicine

Cell DifferentiationOptogeneticsCell SpecializationSystematic ComparisonRegenerative Medicine +17

CRX Expression in Pluripotent Stem Cell-Derived Photoreceptors Marks a Transplantable Subpopulation of Early Cones

Joseph Collin, Darin Zerti, Rachel Queen, +10

Stem Cells

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina

Birthe Dorgau, Alexander Chaudhary, Marina Moya Molina, +12

Stem Cells Translational Medicine

Ocular DiseaseCompounds AffectingOptogeneticsOxidative StressMedicinal Chemistry +20