Topoisomerase I-Mediated Antiproliferative Activity of Enantiomerically Pure Fluorinated Homocamptothecins

Olivier Lavergne, Danièle Demarquay, Christian Bailly, +11

Journal of Medicinal Chemistry

Homocamptothecin, an E-Ring-Modified Camptothecin Analogue, Generates New Topoisomerase I-Mediated DNA Breaks

Christian Bailly, Amélie Lansiaux, Laurent Dassonneville, +5

Biochemistry

Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric Gα/Gβγ Protein Complex

Grégoire Prévost, M. O. Lonchampt, Susan L. Holbeck, +18

Cancer Research

Molecular PharmacologyMedicinal ChemistryChemoprevention StrategyNovel TherapyG Protein-coupled Receptor +13

BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II

Olivier Lavergne, Jeremiah J. Harnett, Alain Rolland, +6

Bioorganic & Medicinal Chemistry Letters

MedicineNatural SciencesMolecular BiologyChemical BiologyPharmacology +3

Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: Templates for design

G.M. Allan, Nigel Vicker, Harshani R. Lawrence, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural SciencesDrug DiscoveryMedicine +6

BN80927

Danièle Demarquay, Marion Huchet, Hélène Coulomb, +6

Cancer Research

Reductive StressDna RelaxationCell RegulationMolecular BiologyCell Death +6

The homocamptothecin BN 80915 is a highly potent orally active topoisomerase I poison

Danièle Demarquay, Marion Huchet, Hélène Coulomb, +6

Anti-Cancer Drugs

The Dual Topoisomerase Inhibitor, BN 80927, Is Highly Potent against Cell Proliferation and Tumor Growth

Marion Huchet, Danièle Demarquay, Hélène Coulomb, +5

Annals of the New York Academy of Sciences

MedicineTumor GrowthPharmacologyBn 80927Dual Topoisomerase Inhibitor +8

Butyl 2-(4-[1.1′-biphenyl]-4-yl-1H-imidazol-2-yl)ethylcarbamate, a potent sodium channel blocker for the treatment of neuropathic pain

Anne‐Marie Liberatore, Jocelyne Schulz, Christine Favre‐Guilmard, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryPain DisordersHealth SciencesPain Medicine +11

The Homocamptothecin, BN 80927, Is a Potent Topoisomerase I Poison and Topoisomerase II Catalytic Inhibitor

Danièle Demarquay, Hélène Coulomb, Marion Huchet, +4

Annals of the New York Academy of Sciences

Medicinal ChemistryNatural SciencesMedicineBn 80927Molecular Biology +5