John J. Piwinski

Discovery of (1 <i>R</i> ,5 <i>S</i> )- <i>N</i> -[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2( <i>S</i> )-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2( <i>S</i> )-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor:  A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Srikanth Venkatraman, Stéphane Bogen, Ashok Arasappan et al. · Journal of Medicinal Chemistry · 2006 · 278 citations · Full text

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor

Ashok Arasappan, Frank Bennett, Stéphane Bogen et al. · ACS Medicinal Chemistry Letters · 2010 · 95 citations · Full text

Protease Inhibitors, Medicinal Chemistry, Synthetic Virology +11

Tricyclic Farnesyl Protein Transferase Inhibitors:  Crystallographic and Calorimetric Studies of Structure−Activity Relationships

Corey L. Strickland, Patricia C Weber, William T. Windsor et al. · Journal of Medicinal Chemistry · 1999 · 88 citations · Full text

Amide Carbonyl, Molecular Biology, Complex Formation +17

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones:  Potent NK₁ Antagonists

Gregory A. Reichard, Carmine N. Stengone, Sunil Paliwal et al. · Organic Letters · 2003 · 68 citations

Medicinal Chemistry, Practical Synthesis, Engineering +10

Discovery and SAR of hydantoin TACE inhibitors

Wensheng Yu, Zhuyan Guo, Peter Orth et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 56 citations · Full text

Medicinal Chemistry, Drug Target, Medicine +5