Concepedia

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones:  Potent NK<sub>1</sub> Antagonists

Gregory A. Reichard, Carmine N. Stengone, Sunil Paliwal, Ingrid Mergelsberg, Sapna Majmundar, Cheng Wang, Robert L. Tiberi, Andrew T. McPhail, John J. Piwinski, Neng‐Yang Shih

Organic Letters · 2003 · 68 citations · 5 references

DOI

Concepts

Abstract

[structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.

References

5

α‐Alkylation of Amino Acids without Racemization. Preparation of Either (<i>S</i>)‐ or (<i>R</i>)‐α‐Methyldopa from (<i>S</i>)‐Alanine

Dieter Seebàch, Johannes D. Aebi, Reto Naef et al. · Helvetica Chimica Acta · 1985 · 97 citations

, , +15

Enantioselective synthesis of α‐branched α‐amino acids with bulky substituents

Armido Studer, Dieter Seebàch · Liebigs Annalen · 1995 · 39 citations

, , +11

Selektive Umfunktionalisierung der terminalen Amidgruppe offenkettiger Polyamide <i>via</i> 2‐Oxazolin‐5‐one als Zwischenstufen. Vorläufige Mitteilung

Daniel Obrecht, Heinz Heimgartner · Helvetica Chimica Acta · 1981 · 35 citations

, , +13

3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution

Christopher J. Swain, Brian J. Williams, R. BAKER et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 18 citations

, , +5

Acyclic NK1 antagonists: Replacements for the benzhydryl group.

Christopher J. Swain, Margaret A. Cascieri, Andrew P. Owens et al. · Bioorganic & Medicinal Chemistry Letters · 1994 · 14 citations

, , +6