The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase

Lionel Pintard, John H. Willis, Andrew Willems, +8

Nature

Protein FunctionCell RegulationMolecular BiologyGene RegulationSubstrate-specific Adaptor +5

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

Roland Hjerpe, John S. Bett, Matthew J. Keuss, +14

Cell

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

Akihito Ohta, Frances‐Rose Schumacher, Youcef Mehellou, +6

Biochemical Journal

Hypertension Syndrome InteractsGeneticsImmunologyDisease-causing MutationsBlood Pressure +14

Cytoskeletal Regulation by the Nedd8 Ubiquitin-Like Protein Modification Pathway

Thimo Kurz, Lionel Pintard, John H. Willis, +4

Science

Protein FunctionDevelopmental BiologyCell DivisionMolecular RegulationMeiosis +12

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

Thimo Kurz, Yang-Chieh Chou, Andrew Willems, +5

Molecular Cell

Protein FunctionMolecular BiologyCytoskeletonAntisense TherapyMedicine +2

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

Thimo Kurz, Nurhan Özlü, Fabian Rudolf, +6

Nature

Transcriptional RegulationConserved Protein Dcn-1/dcn1pMolecular RegulationNatural SciencesMolecular Biology +8

Neddylation and Deneddylation of CUL-3 Is Required to Target MEI-1/Katanin for Degradation at the Meiosis-to-Mitosis Transition in C. elegans

Lionel Pintard, Thimo Kurz, Sarah Luke-Glaser, +3

Current Biology

ChromatinMeiosis-to-mitosis TransitionCell DivisionDevelopmental GeneticsGenetics +9

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

Roland Hjerpe, Y. Thomas, Jesse Chen, +5

Biochemical Journal

Ubiquitin ModificationProtein FunctionSignal TransductionFree Nedd8Biochemistry +13

Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Frances‐Rose Schumacher, Keith Siew, Jinwei Zhang, +12

EMBO Molecular Medicine

CSN- and CAND1-dependent remodelling of the budding yeast SCF complex

Aleksandra Zemla, Y. Thomas, Sylwia Kędziora, +4

Nature Communications