Pearl Lee

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

Oliver D.K. Maddocks, Dimitris Athineos, Eric C. Cheung et al. · Nature · 2017 · 598 citations

Tumor Biology, Dietary Serine, Chemoprevention Strategy +11

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

Fuming Li, Peiwei Huangyang, Michelle Burrows et al. · Nature Cell Biology · 2020 · 194 citations · Full text

Signaling Pathway, Fbp1 Loss Disrupts, Liver Physiology +7

HDAC6 inhibition enhances 17-AAG–mediated abrogation of hsp90 chaperone function in human leukemia cells

Rekha Rao, Warren Fiskus, Yonghua Yang et al. · Blood · 2008 · 186 citations · Full text

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

Eric C. Cheung, Dimitris Athineos, Pearl Lee et al. · Developmental Cell · 2013 · 181 citations · Full text

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity

Joshua D. Ochocki, Sanika Khare, Daniel Ackerman et al. · Cell Metabolism · 2018 · 133 citations · Full text

Polyamine Toxicity, Urology, Genitourinary Cancer +4