Matthew Heindel

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

Jeffrey F. Waring, Rita Ciurlionis, Robert A. Jolly et al. · Toxicology Letters · 2001 · 317 citations

Pharmacy, Molecular Genetics, Toxicology +16

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in <i>ob/ob</i> Mice

Rebecca J. Gum, Lori L. Gaede, Sandra Koterski et al. · Diabetes · 2003 · 198 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor

Jeffrey F. Waring, Rebecca J. Gum, David C. Morfitt et al. · Toxicology · 2002 · 87 citations

Life Sciences, Molecular Biology, Toxicology +16

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes11Abbreviations: MMP, matrix metalloproteinase; MMPI, matrix metalloproteinase inhibitor; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; NBD-PE, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; and MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; DMSO, dimethylsulfoxide; HPLC, high performance liquid chromatography.

Rebecca J. Gum, Dean Hickman, Jane A. Fagerland et al. · Biochemical Pharmacology · 2001 · 56 citations

Life Sciences, Biochemistry, Pharmacology +11

Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Rebecca J. Gum, Lori L. Gaede, Matthew Heindel et al. · Molecular Endocrinology · 2003 · 47 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +16