Birong Zhang

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

James F. Blake, Rui Xu, Josef R. Bencsik et al. · Journal of Medicinal Chemistry · 2012 · 188 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 135 citations · Full text

Medicine, Oncology, Pharmacology +15

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

Sue J. Sohn, Kathy Barrett, Anne van Abbema et al. · The Journal of Immunology · 2013 · 126 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Lead identification of novel and selective TYK2 inhibitors

Jun Liang, Vickie Tsui, Anne van Abbema et al. · European Journal of Medicinal Chemistry · 2013 · 123 citations · Full text

Pharmacy, Chemical Biology, Chemistry +14

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Jun Liang, Anne van Abbema, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2013 · 97 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17