Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization

Binghe Tan, Xiujuan Shi, Jie Zhang, +10

Cancer Research

Blocking P2X7-Mediated Macrophage Polarization Overcomes Treatment Resistance in Lung Cancer

Juliang Qin, Xiaoyu Zhang, Binghe Tan, +9

Cancer Immunology Research

The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation

Nannan Wu, Xuan-Nhi Nguyen, Li Wang, +15

PLoS Pathogens

Viral ReplicationSynthetic VirologyImmunologyViral PathogenesisInnate Immunity +17

Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice

Xiaoyu Zhang, Juliang Qin, Yihan Zhao, +7

Nutrition Research

ObesityNutritionMetabolic SyndromeHepatologyLipid Accumulation +11

LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment

Na Zhang, Xiaohong Liu, Juliang Qin, +10

Molecular Therapy

Cancer ImmunosurveillanceCar-t Cell TraffickingImmunologyImmunoeditingImmunosuppressive Tumor Microenvironment +5

Extracellular ADP facilitates monocyte recruitment in bacterial infection via ERK signaling

Xiaoyu Zhang, Juliang Qin, Junyan Zou, +8

Cellular and Molecular Immunology

Host ResponseBacterial InfectionsSignal TransductionExtracellular AdpMicrobial Pathogens +12

TLR-Activated Gap Junction Channels Protect Mice against Bacterial Infection through Extracellular UDP Release

Juliang Qin, Guangxu Zhang, Xiaoyu Zhang, +6

The Journal of Immunology

ADP/P2Y1 aggravates inflammatory bowel disease through ERK5-mediated NLRP3 inflammasome activation

Chengfei Zhang, Juliang Qin, Su Zhang, +9

Mucosal Immunology

InflammationAnti-inflammatorySignal TransductionAutoimmune DiseaseImmunology +10

FFAR2 expressing myeloid-derived suppressor cells drive cancer immunoevasion

Zeda Zhao, Juliang Qin, Ying Qian, +11

Journal of Hematology & Oncology

Presenilin 2 deficiency facilitates Aβ-induced neuroinflammation and injury by upregulating P2X7 expression

Juliang Qin, Xiaoyu Zhang, Ziqiang Wang, +6

Science China Life Sciences

InflammationNeurodegenerative DiseasesMolecular NeuroscienceMedicineImmunology +10