Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

Johannes M. F. G. Aerts, Roelof Ottenhoff, Andrew Powlson, +10

Diabetes

Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity

Jin‐Hyo Kim, Ricardo Resende, Tom Wennekes, +12

Science

Identification of the Non-lysosomal Glucosylceramidase as β-Glucosidase 2

Rolf G. Boot, Marri Verhoek, Wilma E. Donker‐Koopman, +5

Journal of Biological Chemistry

Development of Adamantan-1-yl-methoxy-Functionalized 1-Deoxynojirimycin Derivatives as Selective Inhibitors of Glucosylceramide Metabolism in Man

Tom Wennekes, Richard J. B. H. N. van den Berg, Wilma Donker, +4

The Journal of Organic Chemistry

Bioorganic ChemistryGlycobiologySelective InhibitorsPharmacotherapyChemical Biology +17

N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses

Frederik Broszeit, N. Tzarum, Xueyong Zhu, +17

Cell Reports

Hydrolytic and Thermal Stability of Organic Monolayers on Various Inorganic Substrates

Nagendra S. Bhairamadgi, Sidharam P. Pujari, Florencio Gerardo Trovela, +9

Langmuir

Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation

Tom Wennekes, Alfred J. Meijer, Albert K. Groen, +15

Journal of Medicinal Chemistry

GlycobiologyInsulin SignalingGastrointestinal Peptide HormoneObesityMetabolic Syndrome +16

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Andrew J. Thompson, R.J. Williams, Z. Hakki, +11

Proceedings of the National Academy of Sciences

A Protein‐Based Pentavalent Inhibitor of the Cholera Toxin B‐Subunit

Thomas R. Branson, Tom E. McAllister, Jaime Garcia‐Hartjes, +6

Angewandte Chemie International Edition

Drug TargetToxinologyPentavalent NeoglycoproteinProtein AssemblyProtein Toxins +14

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

D. Lahav, Bing Liu, Richard J. B. H. N. van den Berg, +15

Journal of the American Chemical Society

Drug TargetGlycobiologySelective InhibitorsChemical BiologyHuman Nonlysosomal Glucosylceramidase +18