Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration

Hongwei Qin, Jessica A. Buckley, Xinru Li, +9

Journal of Neuroscience

Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

Ashley S. Harms, Aaron D. Thome, Zhaoqi Yan, +7

Experimental Neurology

InflammationNeurodegenerative DiseasesAutoimmune DiseaseMedicineParkinson Disease +11

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Andrew S. Mendiola, Jae Kyu Ryu, Sophia Bardehle, +27

Nature Immunology

InflammationReductive StressTranscriptional RegulationNeurodegenerative DiseasesMedicine +9

Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury

Jiping Zhao, Hao Yu, Yudong Liu, +9

American Journal of Physiology-Lung Cellular and Molecular Physiology

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

Mario Merlini, Victoria A. Rafalski, Keran Ma, +21

Nature Neuroscience

NeurophysiologyBrain Network HyperexcitabilityBrain-immune InteractionNeurologyNeuroscience +3

Dysregulation of the Adaptive Immune System in Patients With Early-Stage Parkinson Disease

Zhaoqi Yan, Wei Yang, Hairong Wei, +5

Neurology Neuroimmunology & Neuroinflammation

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Andrew S. Mendiola, Zhaoqi Yan, Karuna Dixit, +18

Nature Immunology

Tissue-Resident Macrophages Promote Renal Cystic Disease

Kurt A. Zimmerman, Cheng Song, Zhang Li, +15

Journal of the American Society of Nephrology

Fibrin drives thromboinflammation and neuropathology in COVID-19

Jae Kyu Ryu, Zhaoqi Yan, Mauricio Montaño, +41

Nature

Deficiency of Socs3 leads to brain-targeted experimental autoimmune encephalomyelitis via enhanced neutrophil activation and ROS production

Zhaoqi Yan, Wei Yang, Luke Parkitny, +9

JCI Insight

ImmunologyRos ProductionImmune DysregulationOxidative StressNeuroinflammation +17