Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

Dimitrios Davalos, Jae Kyu Ryu, Mario Merlini, +13

Nature Communications

Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model

Mario Merlini, Victoria A. Rafalski, Pamela E. Rios Coronado, +11

Neuron

Neurodegenerative DiseasesAlzheimer's DiseaseDisease ModelMedicineDegenerative Pathology +10

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

Rosa Chiara Paolicelli, Ali Jawaid, Christopher M. Henstridge, +11

Neuron

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

Mario Merlini, Éric P. Meyer, Alexandra Ulmann‐Schuler, +1

Acta Neuropathologica

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

Mario Merlini, Tunahan Kirabali, Luka Kulic, +2

Neurodegenerative Diseases

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Andrew S. Mendiola, Jae Kyu Ryu, Sophia Bardehle, +27

Nature Immunology

InflammationReductive StressTranscriptional RegulationNeurodegenerative DiseasesMedicine +9

T-cell brain infiltration and immature antigen-presenting cells in transgenic models of Alzheimer’s disease-like cerebral amyloidosis

Maria Teresa Ferretti, Mario Merlini, Claudia Späni, +7

Brain Behavior and Immunity

Cerebral Beta-amyloidosisAdaptive Immune SystemImmunologyImmunologic MechanismImmature Antigen-presenting Cells +16

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

Mario Merlini, Victoria A. Rafalski, Keran Ma, +21

Nature Neuroscience

NeurophysiologyBrain Network HyperexcitabilityBrain-immune InteractionNeurologyNeuroscience +3

Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

Grietje Krabbe, Sakura Minami, Jon Iker Etchegaray, +19

Proceedings of the National Academy of Sciences

Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer’s disease-related microvascular cerebral amyloid angiopathy

Mario Merlini, Debora Wanner, Roger M. Nitsch

Acta Neuropathologica

Collagen ContentAlzheimer ’Tau Pathology-dependent RemodellingNeurovascular DiseaseAlzheimer's Disease +19