Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

Jae Kyu Ryu, Victoria A. Rafalski, Anke Meyer‐Franke, +32

Nature Immunology

InflammationNeurodegenerative DiseasesMedicineImmunologyFibrinolysis +6

Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

Mark A. Petersen, Jae Kyu Ryu, Kae-Jiun Chang, +25

Neuron

InflammationThrombosisOligodendrocyte Progenitor CellsDevelopmental BiologyVascular Damage +13

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Andrew S. Mendiola, Jae Kyu Ryu, Sophia Bardehle, +27

Nature Immunology

InflammationReductive StressTranscriptional RegulationNeurodegenerative DiseasesMedicine +9

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

Mario Merlini, Victoria A. Rafalski, Keran Ma, +21

Nature Neuroscience

NeurophysiologyBrain Network HyperexcitabilityBrain-immune InteractionNeurologyNeuroscience +3

Defining blood-induced microglia functions in neurodegeneration through multiomic profiling

Andrew S. Mendiola, Zhaoqi Yan, Karuna Dixit, +18

Nature Immunology

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina

Sandra M. Cardona, Andrew S. Mendiola, Ya-Chin Yang, +3

ASN NEURO

Fibrin drives thromboinflammation and neuropathology in COVID-19

Jae Kyu Ryu, Zhaoqi Yan, Mauricio Montaño, +41

Nature

Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis

Cory M. Willis, Alexandra M. Nicaise, Antoine Ménoret, +9

Proceedings of the National Academy of Sciences

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant

Sandra M. Cardona, Sangwon V. Kim, Kaira A. Church, +10

Frontiers in Cellular Neuroscience

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy

Andrew S. Mendiola, Rolando Garza, Sandra M. Cardona, +4

Frontiers in Cellular Neuroscience