O. Denneny

Hypoxic human cancer cells are sensitized to BH-3 mimetic–induced apoptosis via downregulation of the Bcl-2 protein Mcl-1

Luke Harrison, Dimitra Micha, Martin Brandenburg et al. · Journal of Clinical Investigation · 2011 · 49 citations · Full text

Apoptosis, Cell Death, Cancer Biology +17

Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

Sarah Danson, Peter Johnson, Tim Ward et al. · Annals of Oncology · 2011 · 34 citations

Pharmacodynamic Study, Pharmaceutical Science, Pharmacological Study +7

BMX Acts Downstream of PI3K to Promote Colorectal Cancer Cell Survival and Pathway Inhibition Sensitizes to the BH3 Mimetic ABT-737

Danielle S. Potter, Paul Kelly, O. Denneny et al. · Neoplasia · 2014 · 23 citations · Full text

Validation of the comet-X assay as a pharmacodynamic assay for measuring DNA cross-linking produced by the novel anticancer agent RH1 during a phase I clinical trial

Sarah Danson, Malcolm Ranson, O. Denneny et al. · Cancer Chemotherapy and Pharmacology · 2007 · 22 citations

Comet-x Assay, Medicine, Pharmacology +9

Generation of assays and antibodies to facilitate the study of human 5′-tyrosyl DNA phosphodiesterase

Graeme Thomson, Amanda J. Watson, Keith W. Caldecott et al. · Analytical Biochemistry · 2013 · 17 citations

Engineering, Molecular Biological Method, Bioanalysis +7