Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1

Zuanning Yuan, Alberto Riera, Lin Bai, +9

Nature Structural & Molecular Biology

EngineeringProtein AssemblyNatural SciencesProtein X-ray CrystallographyMolecular Biology +5

Hxk2 Regulates the Phosphorylation State of Mig1 and Therefore Its Nucleocytoplasmic Distribution

Deifilia Ahuatzi, Alberto Riera, Rafael Pela ́ez, +2

Journal of Biological Chemistry

Molecular BiologyCellular PhysiologySignaling PathwayCell RegulationAutophagy +15

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

Jingchuan Sun, Cécile Evrin, Stefan A. Samel, +6

Nature Structural & Molecular Biology

Nucleic Acid ChemistryProtein AssemblyNatural SciencesMedicineNucleic Acid Biochemistry +7

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

Alejandra Fernandez‐Cid, Alberto Riera, Silvia Tognetti, +7

Molecular Cell

Supramolecular AssemblyMultistep ReactionNatural SciencesSelf-assemblyMolecular Self-assembly +7

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA

Stefan A. Samel, Alejandra Fernandez‐Cid, Jingchuan Sun, +5

Genes & Development

Protein AssemblyClosed Ring StructureMolecular BiologyNucleic Acid ChemistryProtein Folding +16

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

Jingchuan Sun, Alejandra Fernandez‐Cid, Alberto Riera, +5

Genes & Development

Glucose sensing through the Hxk2-dependent signalling pathway

Fernando Moreno, Deifilia Ahuatzi, Alberto Riera, +2

Biochemical Society Transactions

Molecular BiologyInsulin SignalingSignaling PathwayHexokinase 2Hxk2-dependent Signalling Pathway +16

Hexokinase 2 Is an Intracellular Glucose Sensor of Yeast Cells That Maintains the Structure and Activity of Mig1 Protein Repressor Complex

Montserrat Rojo de la Vega, Alberto Riera, Alejandra Fernandez‐Cid, +2

Journal of Biological Chemistry

Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

Zuanning Yuan, Sarah Schneider, Thomas Dodd, +9

Proceedings of the National Academy of Sciences

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization

Cécile Evrin, Alejandra Fernandez‐Cid, J. Zech, +6

Nucleic Acids Research