Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

Todd G. Kirchgessner, Paul G. Sleph, Jacek Ostrowski, +28

Cell Metabolism

InflammationMetabolic SyndromeCirculating NeutrophilsOxysterolHuman Lipid +10

P2Y6 Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development

Ricardo Alexandrino Garcia, Mujing Yan, Debra Search, +15

PLoS ONE

Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of <i>N</i>-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-<i>N</i>,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ET_A Selective Antagonist

Natesan Murugesan, Zhengxiang Gu, Steven H. Spergel, +18

Journal of Medicinal Chemistry

Receptor Antagonist N-Molecular PharmacologyMedicinal ChemistryPharmacological StudyBiochemistry +13

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction

Ricardo Alexandrino Garcia, John A. Lupisella, Bruce R. Ito, +25

JACC Basic to Translational Science

Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle

Nicholas J. Lodge, Rongan Zhang, Nelly N. Halaka, +1

European Journal of Pharmacology

Molecular PhysiologyEtb ReceptorsMedicineVascular AdaptationPhysiology +7

Biphenylsulfonamide Endothelin Antagonists:  Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-<i>N</i>- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)

Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, +24

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceBiochemistryDisubstituted Analogues +13

Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)

Jun Li, Lawrence J. Kennedy, Yan Shi, +44

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryCrystal StructureOxysterolBiochemistry +12

Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ET_A Antagonists

Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, +12

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal Chemistry‘ -Oxazolyl BiphenylsulfonamidesBiochemistryMedicine +12

(3<i>R,</i>5<i>S,E</i>)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1<i>H</i>-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential

Saleem Ahmad, Cort S. Madsen, Philip D. Stein, +28

Journal of Medicinal Chemistry

Pharmaceutical ScienceCell SelectivityHyperlipidemiaPharmacotherapyPharmaceutical Chemistry +18

Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction

Guixue Yu, Helen J. Mason, Ximao Wu, +14

Journal of Medicinal Chemistry

Medicinal ChemistryUrologyOrally Bioavailable PotentSelective Pde5 InhibitorsErectile Dysfunction +8