HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Nicolas Chomont, Mohamed El‐Far, Petronela Ancuța, +13

Nature Medicine

Homeostatic ProliferationViral PersistenceHuman RetrovirusImmunologyHiv Reservoir Size +8

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

Denis Gaucher, René Therrien, Nadia Kettaf, +23

The Journal of Experimental Medicine

Adaptive Immune SystemInnate Immune SystemImmunologyImmune RegulationImmunologic Mechanism +19

HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity

Souheil-Antoine Younes, Bader Yassine‐Diab, Alain R. Dumont, +4

The Journal of Experimental Medicine

Adaptive Immune SystemImmunologyImmune RegulationImmunodominanceHiv-1 Viremia +16

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells

Catherine Riou, Bader Yassine‐Diab, Julien van Grevenynghe, +12

The Journal of Experimental Medicine

T-regulatory CellApoptosisImmunologyImmune RegulationCell Death +16

Human Immunodeficiency Virus Type 1-Specific CD8⁺T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4⁺T Cells

Hendrik Streeck, Jonathan Jolin, Qi Ying, +15

Journal of Virology

ImmunodeficienciesViral ImmunityImmune RegulationImmunologyImmunodominance +21

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4⁺T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2

Christiana Iyasere, John C. Tilton, Alison J. Johnson, +13

Journal of Virology

Exogenous Il-2ImmunodeficienciesImmune RegulationImmunologyImmunodominance +24

Transcription factor FOXO3a controls the persistence of memory CD4+ T cells during HIV infection

Julien van Grevenynghe, Francesco A. Procopio, Zhong He, +16

Nature Medicine

Transcription Factor Foxo3aHuman RetrovirusImmunologyHiv InfectionAntiviral Response +6

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

Stéphane Pillet, Éric Aubin, Sonia Trépanier, +6

Clinical Immunology

ImmunologyImmunodominanceStrain SelectionCd4 T Cell ResponsesFlu Vaccination +19

CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction

Yoav Peretz, Zhong He, Yu Shi, +14

PLoS Pathogens

Recognition of a Defined Region within p24 Gag by CD8⁺T Cells during Primary Human Immunodeficiency Virus Type 1 Infection in Individuals Expressing Protective HLA Class I Alleles

Hendrik Streeck, Mathias Lichterfeld, Galit Alter, +11

Journal of Virology

HistocompatibilityImmunodeficienciesHla ImmunogeneticsImmunologyImmune Regulation +22