Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients

Jacob J. Chabon, Andrew D. Simmons, Alexander F. Lovejoy, +19

Nature Communications

Tumour DnaCapp-seq Ctdna AnalysisMedicineTumour HeterogeneityPathology +13

Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC

Annette O. Walter, Robert Tjin Tham Sjin, Henry J. Haringsma, +27

Cancer Discovery

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer

Khyati N. Shah, Roma Bhatt, Julia Rotow, +22

Nature Medicine

MedicineReceptor Tyrosine KinaseCell BiologyTumor SuppressorCancer Genetics +5

Bronchial and Peripheral Murine Lung Carcinomas Induced by T790M-L858R Mutant EGFR Respond to HKI-272 and Rapamycin Combination Therapy

Danan Li, Takeshi Shimamura, Hongbin Ji, +20

Cancer Cell

Rapamycin Combination TherapyMedicineImmunologyPathologyBronchial Neoplasm +7

Inactivation of Capicua drives cancer metastasis

Ross A. Okimoto, Frank Breitenbuecher, Victor Olivas, +16

Nature Genetics

Tumor BiologyMedicineCancer BiologyCell BiologyTumor Microenvironment +1

Hsp90 Inhibition Suppresses Mutant EGFR-T790M Signaling and Overcomes Kinase Inhibitor Resistance

Takeshi Shimamura, Danan Li, Hongbin Ji, +19

Cancer Research

Radiation OncologySignal TransductionCell RegulationHsp90 InhibitorsSignaling Pathway +13

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272

Yuko Minami, Takeshi Shimamura, Kinjal Shah, +14

Oncogene

Oncogenic AgentMedicineCell BiologyCancer GeneticsSystems Biology +4

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo

Denise M. Kenski, Abby J. Cooper, Jing Li, +10

Nucleic Acids Research

Chemical ModificationMolecular BiologyCellular PhysiologyAntisense TherapyCell Signaling +18

Nucleobase and Ribose Modifications Control Immunostimulation by a MicroRNA-122-mimetic RNA

Hayden Peacock, Raymond V. Fucini, Prasanna Jayalath, +5

Journal of the American Chemical Society

EngineeringImmunologyMolecular BiologyTherapeuticsImmunotherapy +15

<i>In Vitro</i> and <i>In Vivo</i> Characterization of Irreversible Mutant-Selective EGFR Inhibitors That Are Wild-Type Sparing

Robert Tjin Tham Sjin, Kwangho Lee, Annette O. Walter, +21

Molecular Cancer Therapeutics

Drug TargetingNovel TherapyNormal Lung TissueMedicineCancer Growth +12