Brett A. Howell - Concepedia

Author

Brett A. Howell

University of North Carolina at Chapel Hill ORCID

Also Known As

B. A. Howell, BA Howell, Brett A Howell, Brett A. Howell, Brett Howell, Brouwer, Kim L. R., Diane Longo, Howell, Brett A., Siler, Scott Q., Yang, Kyunghee

Publications

1.6K

Citations

H-Index

Concepts

All Affiliations

University of North Carolina at Chapel Hill Research Triangle Park Foundation University of Florida Triangle Simulations Plus (United States)

About

Brett A. Howell is an author at University of North Carolina at Chapel Hill specializing in medicine, pharmacology, and hepatology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	14	16	588
2	Biochemistry	5	5	126
3	Health Sciences	4	4	164
4	Engineering	1	1	61
5	Allergy	1	1	31

Brett A. Howell

Publications

1.1K

Citations

H-Index

Page 1

	Year	Citations
In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI Brett A. Howell, Yuching Yang, Rukmini Kumar, Journal of Pharmacokinetics and Pharmacodynamics Pharmacokinetic ModelingHepatologyPharmacological StudyMedicineLiver Physiology	2012	105
Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury Jeffrey L. Woodhead, Kyunghee Yang, Scott Q. Siler, Frontiers in Pharmacology	2014	92
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors Jeffrey L. Woodhead, William J. Brock, Sharin E. Roth, Toxicological Sciences ImmunologyPharmacotherapyEvaluate Putative MechanismsHepatotoxicityHealth Sciences	2016	89
An Analysis of N-Acetylcysteine Treatment for Acetaminophen Overdose Using a Systems Model of Drug-Induced Liver Injury Jeffrey L. Woodhead, Brett A. Howell, Yuching Yang, Journal of Pharmacology and Experimental Therapeutics	2012	79
Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling Jeffrey L. Woodhead, Kyunghee Yang, David Oldach, Pharmaceutical Research	2019	63
Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches Sudin Bhattacharya, Lisl K.M. Shoda, Qiang Zhang, Frontiers in Physiology EngineeringToxicological MechanismToxicologyBiostatisticsHepatotoxicity	2012	61
Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling Jeffrey L. Woodhead, Scott Q. Siler, Brett A. Howell, Toxicological Sciences Mitochondrial DysfunctionImmunologyPharmacotherapyExperimental PharmacologyOxidative Stress	2022	46
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072 Franziska Paech, Simon Messner, Jochen Spickermann, Archives of Toxicology HepatologyAntibioticsMedicineLiver PhysiologyHepatotoxicity	2017	43
Quantitative Systems Toxicology Analysis of<i>In Vitro</i>Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury Diane Longo, Jeffrey L. Woodhead, Paul Walker, Toxicological Sciences Mitochondrial DysfunctionPathologyCholangiopathiesQuantitative Systems ToxicologyPhysiologically-based Pharmacokinetic Modeling	2018	43
MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics Yuching Yang, Sashi Nadanaciva, Yvonne Will, Pharmaceutical Research	2014	41

Page 1