William J. Brock - Concepedia

Author

William J. Brock

University of North Carolina at Chapel Hill ORCID

Also Known As

Brock, William J., Freeman, Kimberly M., Lu, Yang, W J Brock, W. Brock, W. J. Brock, W.J. Brock, WILLIAM J. BROCK, William Brock, William J Brock

Publications

947

Citations

H-Index

Concepts

All Affiliations

University of North Carolina at Chapel Hill Scientific Consulting Group Otsuka (United States)Pharmaceutical Product Development (United States)DuPont (United States)

About

William J. Brock is an author at University of North Carolina at Chapel Hill specializing in medicine, pharmacology, and toxicology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	10	10	353
2	Health Sciences	5	5	162
3	Public Health	4	4	124
4	Allergy	3	3	79
5	Biochemistry	1	1	12

William J. Brock

Publications

802

Citations

H-Index

Page 1

	Year	Citations
Comparative Pulmonary Toxicity Inhalation and Instillation Studies with Different TiO2 Particle Formulations: Impact of Surface Treatments on Particle Toxicity D. B. Warheit, William J. Brock, K. P. Lee, Toxicological Sciences	2005	222
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors Jeffrey L. Woodhead, William J. Brock, Sharin E. Roth, Toxicological Sciences ImmunologyPharmacotherapyEvaluate Putative MechanismsHepatotoxicityHealth Sciences	2016	89
Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach Merrie Mosedale, Yunjung Kim, William J. Brock, Toxicological Sciences Bile Acid HomeostasisImmunologyPathologyCandidate Risk FactorsCirrhosis	2016	52
Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury? Jason R. Slizgi, Yang Lu, Kenneth R. Brouwer, Toxicological Sciences	2015	50
miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model Merrie Mosedale, J. Scott Eaddy, O. Joseph Trask, Toxicological Sciences ImmunotoxicologyPlasma CmaxIdili Drug TolvaptanImmunologyCell Death	2017	49
Acute and subchronic toxicity of 1,1-dichloro-1-fluoroethane (HCFC-141 b) William J. Brock, Henry J. Trochimowicz, R Millischer, Food and Chemical Toxicology Environmental ChemistryMedicineEnvironmental HealthForensic ToxicologyFluorous Synthesis	1995	45
Oral Repeat Dose and Reproductive Toxicity of the Chlorinated Flame Retardant Dechlorane Plus William J. Brock, Raymond E. Schroeder, Christy A. McKnight, International Journal of Toxicology Animal PhysiologyRdt PhaseInfertilityGavage InjuryEndocrine Disruptors	2010	36
Characterization of uptake of steroid glucuronides into isolated male and female rat hepatocytes. William J. Brock, Mary Vore Journal of Pharmacology and Experimental Therapeutics	1984	35
Food Safety: Risk Assessment Methodology and Decision-Making Criteria William J. Brock, Joseph V. Rodricks, Alan M. Rulis, International Journal of Toxicology Risk Assessment MethodologyNutritional GuidelinesEnvironmental HealthRisk ManagementCumulative Risk Assessment	2003	25
Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity James J. Beaudoin, William J. Brock, Paul B. Watkins, Clinical Pharmacology & Therapeutics PathologyCholangiopathiesAdpkd ProgressionQuantitative Systems ToxicologyMrp2 Dysfunction	2020	22

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