William J. Brock

Comparative Pulmonary Toxicity Inhalation and Instillation Studies with Different TiO2 Particle Formulations: Impact of Surface Treatments on Particle Toxicity

D. B. Warheit, William J. Brock, K. P. Lee et al. · Toxicological Sciences · 2005 · 222 citations

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

Jeffrey L. Woodhead, William J. Brock, Sharin E. Roth et al. · Toxicological Sciences · 2016 · 89 citations · Full text

Immunology, Pharmacotherapy, Evaluate Putative Mechanisms +20

Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach

Merrie Mosedale, Yunjung Kim, William J. Brock et al. · Toxicological Sciences · 2016 · 52 citations · Full text

Bile Acid Homeostasis, Immunology, Pathology +23

Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

Jason R. Slizgi, Yang Lu, Kenneth R. Brouwer et al. · Toxicological Sciences · 2015 · 50 citations · Full text

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model

Merrie Mosedale, J. Scott Eaddy, O. Joseph Trask et al. · Toxicological Sciences · 2017 · 49 citations · Full text

Immunotoxicology, Plasma Cmax, Idili Drug Tolvaptan +25