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In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

Pharmacokinetic ModelingHepatologyPharmacological StudyMedicineLiver PhysiologyImmunologySpecies Response ComparisonsMathematical ModelToxicologyVivo ExtrapolationHepatotoxicityPharmacologyDrug-induced Liver InjuryPharmacokineticsPharmacodynamic Modeling