Carson W. Reed

Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu₇ Negative Allosteric Modulator (NAM) in Vivo Tool Compound: <i>N</i>-(2-(1<i>H</i>-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)

Carson W. Reed, Samantha E. Yohn, Jordan P. Washecheck et al. · Journal of Medicinal Chemistry · 2019 · 27 citations · Full text

VU6010608, a Novel mGlu₇ NAM from a Series of <i>N</i>-(2-(1<i>H</i>-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides

Carson W. Reed, Kevin McGowan, Paul K. Spearing et al. · ACS Medicinal Chemistry Letters · 2017 · 24 citations · Full text

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Xin Lin, Nicole M. Fisher, Shalini Dogra et al. · Journal of Biological Chemistry · 2022 · 20 citations · Full text

Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278

Carson W. Reed, Jordan P. Washecheck, Marc C. Quitlag et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 16 citations · Full text

Mglu7 Nams, Combinatorial Chemistry, Biochemistry +4

Use of chemical probes to explore the toxicological potential of the K+/Cl− cotransporter (KCC) as a novel insecticide target to control the primary vector of dengue and Zika virus, Aedes aegypti

Francis J. Prael, Rui Chen, Zhilin Li et al. · Pesticide Biochemistry and Physiology · 2018 · 13 citations · Full text

Synaptic Transmission, Neurotransmitter, Neurotransmission +24