Jacob J. Kalbfleisch

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Xin Lin, Nicole M. Fisher, Shalini Dogra et al. · Journal of Biological Chemistry · 2022 · 22 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu₇ Positive Allosteric Modulator Tool Compound

Carson W. Reed, Jacob J. Kalbfleisch, Madison J. Wong et al. · ACS Medicinal Chemistry Letters · 2020 · 14 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Persistent challenges in the development of an mGlu7 PAM in vivo tool compound: The discovery of VU6046980

Jacob J. Kalbfleisch, Alice L. Rodriguez, Kelly Weiss et al. · Bioorganic & Medicinal Chemistry Letters · 2022 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening

Shannon T. Smith, Jackson B. Cassada, Lukas von Bredow et al. · ACS Pharmacology & Translational Science · 2024 · 11 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17