Brian A. Droz

GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

Ricardo J. Samms, Michael E. Christe, Kyla Collins et al. · Journal of Clinical Investigation · 2021 · 204 citations · Full text

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

Takahiro Kawai, Bingfa Sun, Hitoshi Yoshino et al. · Proceedings of the National Academy of Sciences · 2020 · 172 citations · Full text

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

Gang Zhao, Andrew J. Souers, Martin J. Voorbach et al. · Journal of Medicinal Chemistry · 2008 · 139 citations · Full text

Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-<i>N</i>-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Jeffrey J. Rohde, Marina Pliushchev, Bryan K. Sorensen et al. · Journal of Medicinal Chemistry · 2006 · 76 citations · Full text

Medicinal Chemistry, Pharmacological Study, Biochemistry +11

Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

Ricardo J. Samms, Guofang Zhang, Wentao He et al. · Molecular Metabolism · 2022 · 76 citations · Full text