Nobuyoshi Hirose

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Yuko Sato, Koji Atarashi, Damian R. Plichta et al. · Nature · 2021 · 570 citations

Biology, Probiotic, Dysbiosis +9

Binding of a high reactive heparin to human apolipoprotein E: Identification of two heparin-binding domains

Alan D. Cardin, Nobuyoshi Hirose, Dale T. Blankenship et al. · Biochemical and Biophysical Research Communications · 1986 · 112 citations

Hepatology, Biochemistry, High Reactive Heparin +10

Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

Joachim Johansen, Koji Atarashi, Yasumichi Arai et al. · Nature Microbiology · 2023 · 92 citations

Biology, Nutrition, Lifespan Extension +8

Serum Insulin-like Growth Factor-1 in Centenarians: Implications of IGF-1 as a Rapid Turnover Protein

Yasumichi Arai, Nobuyoshi Hirose, K. Yamamura et al. · The Journals of Gerontology Series A · 2001 · 61 citations · Full text

Physical-chemical interaction of heparin and human plasma low-density lipoproteins

Alan D. Cardin, Catherine J. Randall, Nobuyoshi Hirose et al. · Biochemistry · 1987 · 40 citations