Jacob W. Freimer

CRISPR activation and interference screens decode stimulation responses in primary human T cells

Ralf Schmidt, Zachary Steinhart, Madeline Layeghi et al. · Science · 2022 · 291 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +24

GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency

Amy F. Chen, Arthur Liu, Raga Krishnakumar et al. · Cell stem cell · 2018 · 110 citations · Full text

Transcriptional Regulation, Lineage Plasticity, Developmental Biology +8

Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks

Jacob W. Freimer, Oren Shaked, Sahin Naqvi et al. · Nature Genetics · 2022 · 83 citations · Full text

Immune Networks, Autoimmune Disease, Systematic Discovery +11

CRISPR screens decode cancer cell pathways that trigger γδ T cell detection

Murad R. Mamedov, Shane Vedova, Jacob W. Freimer et al. · Nature · 2023 · 82 citations · Full text

Decode Cancer Cell, Immunology, Gene Editing +6

Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

Jacob W. Freimer, TJ Hu, Robert Blelloch · eLife · 2018 · 70 citations · Full text