TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

Chamelli Jhappan, C Stahle, Richard N. Harkins, +3

Cell

Developmental BiologyLiver PhysiologyMammary GlandPathologyCell Development +6

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

Chamelli Jhappan, Daniel Gallahan, C Stahle, +4

Genes & Development

GeneticsCell DifferentiationInduces Neoplastic TransformationCancer BiologyMammary Gland Development +16

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

Lorne J. Hofseth, Shinichi Saito, S. Perwez Hussain, +13

Proceedings of the National Academy of Sciences

ImmunologyCell DeathPathologyCancer BiologyOxidative Stress +16

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

Chamelli Jhappan, Andrew G. Geiser, Edith C. Kordon, +5

The EMBO Journal

Developmental BiologyTissue DevelopmentGrowth HormoneMammary GlandMammary Physiology +8

Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors

Jennifer Guida, Tim A. Ahles, Daniel W. Belsky, +21

JNCI Journal of the National Cancer Institute

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

Edith C. Kordon, Robert A. McKnight, Chamelli Jhappan, +3

Developmental Biology

Developmental BiologyMedicineMammary GlandEpithelial-mesenchymal InteractionsStem Cell Research +7

Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis.

Daniel Gallahan, Chamelli Jhappan, Gertraud W. Robinson, +6

PubMed

Lineage PlasticityDevelopmental BiologyTissue DevelopmentImmunologyTruncated Int3 Gene +13

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis

Richard Sharp, Juan A. Recio, Chamelli Jhappan, +9

Nature Medicine

Signal TransductionSignaling PathwayMedicineMolecular BiologyInk4a/arf Inactivation +4

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

Chamelli Jhappan, Herbert C. Morse, Robert Fleischmann, +2

Nature Genetics

Tumor BiologyMedicineMouse Scid LocusT-cell Tumour SuppressorTumor Suppressor +6

Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach.

Hitoshi Takagi, Chamelli Jhappan, Richard Sharp, +1

Journal of Clinical Investigation

Metabolic SyndromeGrowth HormonePhysiologyPathogenesisGastroenterology +12