Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan

Jesse J. Salk, Kaitlyn Loubet-Senear, Elisabeth Maritschnegg, +15

Cell Reports

PathologyGynecologyClonal Tp53 MutationsCancer BiologyOvarian Cancer +16

Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions

J. Silvio Gutkind, Alfredo Molinolo, Xingyu Wu, +19

JCI Insight

PathologyCancer BiologyTumor BiologyOral CancerOncology +17

Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS)

Daniela Nachmanson, Shenyi Lian, Elizabeth Schmidt, +9

Genome Research

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Brian W. Jones, Jennifer D. Deem, Thomas J. Younts, +8

eLife

Akap7/pka ComplexSynaptic TransmissionCytoskeletonNeurotransmissionStructural Plasticity +16

Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer

Kathryn T. Baker, Daniela Nachmanson, Shilpa Kumar, +5

Molecular Cancer Research

GeneticsPathologyGenomicsOncologyTumor Heterogeneity +14

Characterization of TP53 mutations in Pap test DNA of women with and without serous ovarian carcinoma

Jeffrey D. Krimmel‐Morrison, Talayeh Ghezelayagh, Shenyi Lian, +10

Gynecologic Oncology

Pap Test DnaSomatic VariantMedicineGynecologyPathology +5

The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situ

Daniela Nachmanson, Adam Officer, Hidetoshi Mori, +15

npj Breast Cancer

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats

Stephanie L. Smith‐Roe, Cheryl A. Hobbs, Victoria Hull, +12

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry

Nadia Arang, Simone Lubrano, Damiano Cosimo Rigiracciolo, +5

Journal of Biological Chemistry

Downstream ComponentNatural SciencesGeneticsGene RegulationGenome Engineering +6

A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death

Michael M. Allevato, Sally Trinh, Keiichi Koshizuka, +13

Cancer Letters