Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, +15

Nature

Protein X-ray CrystallographyMolecular BiologyPhase-plate Cryo-em StructureCrystallographyStructural Biology

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Christopher J. Draper-Joyce, Maryam Khoshouei, David M. Thal, +13

Nature

Molecular PharmacologySignal TransductionBiochemistryG Protein-coupled ReceptorReceptor (Biochemistry) +2

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, +15

Nature

Molecular PharmacologySignal TransductionMolecular PhysiologyG Protein-coupled ReceptorReceptor (Biochemistry) +5

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Alisa Glukhova, David M. Thal, Thi Nguyen, +6

Cell

Molecular PharmacologyG Protein-coupled ReceptorFunctional SelectivitySubtype SelectivityReceptor (Biochemistry) +5

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Yi-Lynn Liang, Maryam Khoshouei, Giuseppe Deganutti, +12

Nature

Signal TransductionMolecular PhysiologySignaling PathwayG Protein-coupled ReceptorMedicine +6

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

Xin Zhang, Matthew J. Belousoff, Peishen Zhao, +19

Molecular Cell

Signal TransductionBiochemistryG Protein-coupled ReceptorDifferential Glp-1r BindingMedicine +5

Activation mechanism of PINK1

Zhong Yan Gan, Sylvie Callegari, Simon A. Cobbold, +9

Nature

Signal TransductionSignaling PathwayNatural SciencesMolecular BiologyCytoskeleton +6

Automatic local resolution-based sharpening of cryo-EM maps

Erney Ramírez-Aportela, José Luis Vilas, Alisa Glukhova, +11

Bioinformatics

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Phillip Pymm, Amy Adair, Li‐Jin Chan, +26

Proceedings of the National Academy of Sciences

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

Christopher J. Draper-Joyce, Rebecca F. Bhola, Jinan Wang, +21

Nature

Molecular PharmacologyPositive Allosteric MechanismsMolecular PhysiologyHealth SciencesBiochemistry +10