Megan V. Astle

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Megan V. Astle, Katherine M. Hannan, Puiyee Ng et al. · Oncogene · 2011 · 288 citations · Full text

Medicine, Cell Biology, Oncology +17

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C. Chan, Katherine M. Hannan, Kim Riddell et al. · Science Signaling · 2011 · 238 citations

Life Sciences, Cancer Biology, Molecular Biology +16

The Inositol Polyphosphate 5-Phosphatase, PIPP, Is a Novel Regulator of Phosphoinositide 3-Kinase-dependent Neurite Elongation

Lisa M. Ooms, Clare G. Fedele, Megan V. Astle et al. · Molecular Biology of the Cell · 2005 · 67 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ- <i>Myc</i> Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L. Stanley et al. · Cancer Discovery · 2012 · 64 citations · Full text

Medicine, Oncology, Pharmacology +17

P-Rex1 – a multidomain protein that regulates neurite differentiation

JoAnne E. Waters, Megan V. Astle, Lisa M. Ooms et al. · Journal of Cell Science · 2008 · 45 citations

Medicine, Neurobiology, Neuroscience +16