Helena Käck

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Jason G. Kettle, Husam Alwan, Michał Biśta et al. · Journal of Medicinal Chemistry · 2016 · 135 citations · Full text

Tool Compounds, Chemoprevention Strategy, Selective Inhibitors +18

Crystal structure of diaminopelargonic acid synthase: evolutionary relationships between pyridoxal-5′-phosphate-dependent enzymes

Helena Käck, Jenny Sandmark, Katharine J. Gibson et al. · Journal of Molecular Biology · 1999 · 112 citations

Crystal Structure, Biochemistry, Natural Sciences +7

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)

Kevin Doyle, Hans Lönn, Helena Käck et al. · Journal of Medicinal Chemistry · 2016 · 80 citations · Full text

Drug Target, Clinical Candidate, Pharmacotherapy +19

A Homogeneous in Vitro Functional Assay for Estrogen Receptors: Coactivator Recruitment

Jianwei Liu, Katharine S. Knappenberger, Helena Käck et al. · Molecular Endocrinology · 2003 · 56 citations · Full text

Estrogen Receptor, Gynecology, Female Reproductive Function +19

A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

E. Suzanne Cohen, Claire Dobson, Helena Käck et al. · mAbs · 2014 · 52 citations · Full text

Asthma, Allergy Medicine, Immunology +17