Shuichi Ohnishi

Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine

Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi et al. · Drug Metabolism and Disposition · 2018 · 36 citations · Full text

Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain

Kouki Fuchino, Yasunori Mitsuoka, Moriyasu Masui et al. · Journal of Medicinal Chemistry · 2018 · 33 citations · Full text

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization

Kenji Nakahara, Kouki Fuchino, Kazuo Komano et al. · Journal of Medicinal Chemistry · 2018 · 32 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Pre-clinical Pharmacology +20

Minimal contribution of P-gp on the low brain distribution of naldemedine, a peripherally acting μ-opioid receptor antagonist

Ryosuke Watari, Akihiro MATSUDA, Shuichi Ohnishi et al. · Drug Metabolism and Pharmacokinetics · 2018 · 29 citations

Molecular Pharmacology, Neurophysiology, Medicine +10

Role of Na+/L-carnitine Transporter (OCTN2) in Renal Handling of Pivaloylcarnitine and Valproylcarnitine Formed during Pivalic Acid-containing Prodrugs and Valproic Acid Treatment

Shuichi Ohnishi, Noboru Okamura, Shingo Sakamoto et al. · Drug Metabolism and Pharmacokinetics · 2008 · 27 citations