2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Ellen W. Baxter, Kelly A. Conway, Ludo Kennis, +20

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +17

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

Ludo Kennis, François Bischoff, Carolus J. Mertens, +6

Bioorganic & Medicinal Chemistry Letters

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

François Bischoff, Didier Berthelot, Michel De Cleyn, +14

Journal of Medicinal Chemistry

Peptide ScienceHeterocycle ChemistryChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +17

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X₇ Antagonists

Michael A. Letavic, Brian Lord, François Bischoff, +15

ACS Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryPharmacological CharacterizationHigh Potency P2x7Pharmacological Study +12

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

David C. McGowan, Florence Herschke, Frederik Pauwels, +18

Journal of Medicinal Chemistry

Internal Screening EffortViral HepatitisMedicineImmunologyDual Agonists +13

2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus

Werner Embrechts, Florence Herschke, Frederik Pauwels, +19

Journal of Medicinal Chemistry

ImmunologyAmino AlcoholDual Toll-like ReceptorPharmacotherapyAntiviral Drug +16

Identification and Optimization of Pyrrolo[3,2-<i>d</i>]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B

David C. McGowan, Florence Herschke, Frederik Pauwels, +25

Journal of Medicinal Chemistry

ImmunologyHepatitis BPharmacotherapyNew SeriesAntiviral Drug +14

Anilinotriazoles as potent gamma secretase modulators

Adriana I. Velter, François Bischoff, Didier Berthelot, +17

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryProtein SecretionBiochemistryAntiparasitic AgentNatural Sciences +5

Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists

Serge Pieters, David C. McGowan, Florence Herschke, +17

Bioorganic & Medicinal Chemistry Letters

Toll-like ReceptorsMedicinal ChemistryDrug TargetFunctional SelectivityTlr 7 +8

Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections

Bart Kesteleyn, Florence Herschke, Nicolas Darville, +24

Journal of Medicinal Chemistry