Serge Pieters

2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Ellen W. Baxter, Kelly A. Conway, Ludo Kennis et al. · Journal of Medicinal Chemistry · 2007 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

Ludo Kennis, François Bischoff, Carolus J. Mertens et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Design and Synthesis of a Novel Series of Bicyclic Heterocycles As Potent γ-Secretase Modulators

François Bischoff, Didier Berthelot, Michel De Cleyn et al. · Journal of Medicinal Chemistry · 2012 · 60 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X₇ Antagonists

Michael A. Letavic, Brian Lord, François Bischoff et al. · ACS Medicinal Chemistry Letters · 2013 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

David C. McGowan, Florence Herschke, Frederik Pauwels et al. · Journal of Medicinal Chemistry · 2016 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17