François Bischoff

2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme):  Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Ellen W. Baxter, Kelly A. Conway, Ludo Kennis et al. · Journal of Medicinal Chemistry · 2007 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist

Hilde Lavreysen, Ria Wouters, François Bischoff et al. · Neuropharmacology · 2004 · 138 citations

Medicine, Medicinal Chemistry, Pharmacology +7

[3H]R214127: A Novel High-Affinity Radioligand for the mGlu1 Receptor Reveals a Common Binding Site Shared by Multiple Allosteric Antagonists

Hilde Lavreysen, Cor Janssen, François Bischoff et al. · Molecular Pharmacology · 2003 · 115 citations · Full text

Medicine, Neuroscience, Pharmacology +12

Synthesis, Structure−Activity Relationship, and Receptor Pharmacology of a New Series of Quinoline Derivatives Acting as Selective, Noncompetitive mGlu1 Antagonists

Dominique Mabire, Sophie Coupa, Christophe Adelinet et al. · Journal of Medicinal Chemistry · 2005 · 96 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

Ludo Kennis, François Bischoff, Carolus J. Mertens et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13