APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Emily K. Law, Rena Levin-Klein, Matthew C. Jarvis, +16

The Journal of Experimental Medicine

Somatic VariantOncogenic AgentMedicineApobec3 FamilyPathology +10

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

Shari Orlanski, Verena Labi, Yitzhak Reizel, +8

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyCell SpecializationTissue-specific Dna DemethylationEpigenetics +20

Postnatal DNA demethylation and its role in tissue maturation

Yitzhak Reizel, Ofra Sabag, Yael Skversky‐Blocq, +12

Nature Communications

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism

Nadine M. Shaban, Ke Shi, Kate Lauer, +10

Molecular Cell

Rna-mediated Dimerization MechanismNatural SciencesDna ReplicationMolecular BiologyAntisense Therapy +3

APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis

Sonja M. Wörmann, Amy Zhang, Fredrik I. Thege, +24

Nature Cancer

OncologyPancreatic CancerMedicinePancreatic Cancer MetastasisCancer Genetics +5

A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B

William L. Brown, Emily K. Law, Prokopios P. Argyris, +8

Antibodies

Tumor BiologyMedicineNovel MabImmunologyNative A3b +12

Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

Cameron Durfee, Nuri A. Temiz, Rena Levin-Klein, +13

Cell Reports Medicine

EngineeringCancer BiologyTumor BiologySignature MutationsMolecular Diagnostics +14

A rabbit monoclonal antibody against the antiviral and cancer genomic DNA mutating enzyme APOBEC3B

William L. Brown, Emily K. Law, Michael A. Carpenter, +8

ImmunologyPathologyImmunotherapyCancer BiologyTumor Biology +17

Chromosomal coordination and differential structure of asynchronous replicating regions

Britny Blumenfeld, Hagit Masika, Marganit Farago, +8

Nature Communications

Clonally stable Vκ allelic choice instructs Igκ repertoire

Rena Levin-Klein, Shira Fraenkel, Michal Lichtenstein, +7

Nature Communications