BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Miriam Erlacher, Ewa M. Michalak, Priscilla N. Kelly, +6

Blood

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Espen Melum, André Franke, Christoph Schramm, +40

Nature Genetics

Disease EtiologyImmunologyGenetic EpidemiologyPathologyCholangiopathies +14

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

Miriam Erlacher, Verena Labi, Claudia Manzl, +6

The Journal of Experimental Medicine

MitophagyCell RegulationApoptosis InductionBim-/- MiceLymphocyte Development +13

Caspase-2 activation in the absence of PIDDosome formation

Claudia Manzl, Gerhard Krumschnabel, Florian J. Bock, +6

The Journal of Cell Biology

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates γ irradiation–induced thymic lymphoma development

Verena Labi, Miriam Erlacher, Claudia Manzl, +4

The Journal of Experimental Medicine

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

Verena Labi, Miriam Erlacher, Gerhard Krumschnabel, +5

Genes & Development

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

Shari Orlanski, Verena Labi, Yitzhak Reizel, +8

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologyCell SpecializationTissue-specific Dna DemethylationEpigenetics +20

AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells

Antonio F. Santidrián, Diana M. González‐Gironès, Daniel Iglesias‐Serret, +12

Blood

The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity

Natascha Hermann‐Kleiter, Thomas Gruber, Christina Lutz‐Nicoladoni, +10

Immunity

InflammationAutoimmune DiseaseImmune Cell DevelopmentT-regulatory CellImmunology +5

The NF-κB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

Anette Bauer, Andreas Villunger, Verena Labi, +5

Proceedings of the National Academy of Sciences

Nf-κb Regulator Bcl-3ApoptosisImmunologyImmune RegulationCell Death +16