Ikuko Suzuki‐Takahashi

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

Masatoshi Kitagawa, Hideaki Higashi, Hai Kwan Jung et al. · The EMBO Journal · 1996 · 589 citations · Full text

Signal Transduction, Biochemistry, Molecular Pathway +11

Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase.

Masatoshi Kitagawa, Takayoshi Okabe, H Ogino et al. · PubMed · 1993 · 221 citations

Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors:  New<i>de Novo</i>Design Strategy and Library Design

Teruki Honma, Kyoko Hayashi, Tetsuya Aoyama et al. · Journal of Medicinal Chemistry · 2001 · 200 citations · Full text

Drug Target, Biomolecular Structure Prediction, Molecular Biology +22

Phosphorylation of E2F-1 by cyclin A-cdk2.

Masanobu Kitagawa, Hideaki Higashi, Ikuko Suzuki‐Takahashi et al. · PubMed · 1995 · 108 citations

A Novel Approach for the Development of Selective Cdk4 Inhibitors:  Library Design Based on Locations of Cdk4 Specific Amino Acid Residues

Teruki Honma, Takashi Yoshizumi, Noriaki Hashimoto et al. · Journal of Medicinal Chemistry · 2001 · 107 citations · Full text

Atp Binding Pocket, Biomolecular Structure Prediction, Novel Approach +19