SHP-2 Tyrosine Phosphatase as an Intracellular Target of <i>Helicobacter pylori</i> CagA Protein

Hideaki Higashi, Ryouhei Tsutsumi, Syuichi Muto, +4

Science

Severe GastritisProtein FunctionSignal TransductionIntracellular TargetBiochemistry +13

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

Masatoshi Kitagawa, Hideaki Higashi, Hai Kwan Jung, +8

The EMBO Journal

Signal TransductionBiochemistryMolecular PathwayMedicineNatural Sciences +9

Transgenic expression of <i>Helicobacter pylori</i> CagA induces gastrointestinal and hematopoietic neoplasms in mouse

Naomi Ohnishi, Hitomi Yuasa, Shinya Tanaka, +10

Proceedings of the National Academy of Sciences

Gastrointestinal PharmacologyGastroenterologyPathologyGastric AdenocarcinomaGastric Epithelial Cells +14

Biological activity of the <i>Helicobacter pylori</i> virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Hideaki Higashi, Ryouhei Tsutsumi, Akiko Fujita, +4

Proceedings of the National Academy of Sciences

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

Iraj Saadat, Hideaki Higashi, Chikashi Obuse, +9

Nature

Systems BiologySignal TransductionMolecular PhysiologySignaling PathwayMolecular Pathway +6

Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

Yo Kurashima, Yasuhiro Teishikata, Yukie Yamahashi, +7

Oncogene

Signal TransductionGastrointestinal Pharmacologyβ-Catenin SignalGastroenterologyPathology +8

Attenuation of Helicobacter pylori CagA·SHP-2 Signaling by Interaction between CagA and C-terminal Src Kinase

Ryouhei Tsutsumi, Hideaki Higashi, Megumi Higuchi, +2

Journal of Biological Chemistry

Helicobacter pylori CagA Induces Ras-independent Morphogenetic Response through SHP-2 Recruitment and Activation

Hideaki Higashi, Akihiro Nakaya, Ryouhei Tsutsumi, +10

Journal of Biological Chemistry

Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase.

Masatoshi Kitagawa, Takayoshi Okabe, H Ogino, +7

PubMed

Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with <i>Helicobacter pylori</i> CagA

Ryouhei Tsutsumi, Atsushi Takahashi, Takeshi Azuma, +2

Molecular and Cellular Biology