Hideaki Higashi

SHP-2 Tyrosine Phosphatase as an Intracellular Target of <i>Helicobacter pylori</i> CagA Protein

Hideaki Higashi, Ryouhei Tsutsumi, Syuichi Muto et al. · Science · 2002 · 1K citations

Severe Gastritis, Protein Function, Signal Transduction +15

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

Masatoshi Kitagawa, Hideaki Higashi, Hai Kwan Jung et al. · The EMBO Journal · 1996 · 589 citations · Full text

Signal Transduction, Biochemistry, Molecular Pathway +11

Transgenic expression of <i>Helicobacter pylori</i> CagA induces gastrointestinal and hematopoietic neoplasms in mouse

Naomi Ohnishi, Hitomi Yuasa, Shinya Tanaka et al. · Proceedings of the National Academy of Sciences · 2008 · 580 citations · Full text

Gastrointestinal Pharmacology, Gastroenterology, Pathology +16

Biological activity of the <i>Helicobacter pylori</i> virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Hideaki Higashi, Ryouhei Tsutsumi, Akiko Fujita et al. · Proceedings of the National Academy of Sciences · 2002 · 574 citations · Full text

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

Iraj Saadat, Hideaki Higashi, Chikashi Obuse et al. · Nature · 2007 · 484 citations

Systems Biology, Signal Transduction, Molecular Physiology +8