Jurriaan B. Tuynman

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Louis Vermeulen, Felipe de Sousa e Melo, Maartje van der Heijden et al. · Nature Cell Biology · 2010 · 1.8K citations

Oncology, Medicine, Stem Cells +10

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial

Renu R. Bahadoer, Esmée A. Dijkstra, Boudewijn van Etten et al. · The Lancet Oncology · 2020 · 1.5K citations · Full text

Surgical Oncology, Radiation Therapy, Gastrointestinal Oncology +9

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

Felipe de Sousa e Melo, Xin Wang, Marnix Jansen et al. · Nature Medicine · 2013 · 765 citations

Tumor Biology, Molecularly Distinct Subtype, Gastrointestinal Oncology +11

COLOR III: a multicentre randomised clinical trial comparing transanal TME versus laparoscopic TME for mid and low rectal cancer

Charlotte L. Deijen, Simone Velthuis, Alice Tsai et al. · Surgical Endoscopy · 2015 · 364 citations · Full text

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients

Felipe de Sousa e Melo, Selçuk Çolak, Joyce Y. Buikhuisen et al. · Cell stem cell · 2011 · 331 citations · Full text

Tumor Biology, Medicine, Epigenetic Change +10