Brian M. Linhares

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Szymon Kłossowski, Hongzhi Miao, Katarzyna Kempińska et al. · Journal of Clinical Investigation · 2019 · 223 citations · Full text

Npm1-mutated Models, Hematological Malignancy, Systems Biology +13

Flexible, symmetry-directed approach to assembling protein cages

Aaron Sciore, Min Su, Philipp Koldewey et al. · Proceedings of the National Academy of Sciences · 2016 · 101 citations · Full text

Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction

Dmitry Borkin, Szymon Kłossowski, Jonathan Pollock et al. · Journal of Medicinal Chemistry · 2018 · 58 citations · Full text

Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design

Huimin Cheng, Brian M. Linhares, Wenbo Yu et al. · Journal of Medicinal Chemistry · 2018 · 44 citations · Full text

GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode

Hyo Je Cho, Hao Li, Brian M. Linhares et al. · ACS Chemical Biology · 2018 · 43 citations · Full text

Histone Modifications, Protein Assembly, Structural Bioinformatics +23