Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Marlies Meisel, Reinhard Hinterleitner, Alain Pacis, +28

Nature

Hematological MalignancyMicrobial SignalsPathogenesisImmunologyHematology +3

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, +7

Blood

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

François Binet, Gaël Cagnone, Sergio Crespo‐Garcia, +24

Science

Ocular DiseaseImmunologyRetinal TherapiesOcular Surface PhysiologyInflammation +16

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Sergio Crespo‐Garcia, Pamela R. Tsuruda, Agnieszka Dejda, +24

Cell Metabolism

Ocular DiseaseAngiogenesisOphthalmologyPathological AngiogenesisBcl-xl Inhibition +8

Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A

Manuel Buscarlet, Sylvie Provost, Yassamin Feroz Zada, +4

Blood

The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function

Veneta Krasteva, Manuel Buscarlet, Abigail Diaz‐Tellez, +3

Blood

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance

Manuel Buscarlet, Veneta Krasteva, Lena Ho, +7

Blood

High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential

Lambert Busque, Maxine Sun, Manuel Buscarlet, +10

Blood Advances

ImmunologyBlood CellPathologyCardiovascular Translational ResearchInflammation +25

NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy

Khalil Miloudi, Malika Oubaha, Catherine Ménard, +19

Proceedings of the National Academy of Sciences

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results

Sergio Crespo‐Garcia, Frédérik Fournier, Roberto Diaz-Marin, +26

Nature Medicine

Regenerative MedicineDiabetic RetinopathyOcular DiseaseOphthalmologyMicrovascular Dysfunction +8