Gaël Cagnone

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Ashot S. Harutyunyan, Brian Krug, Haifeng Chen et al. · Nature Communications · 2019 · 392 citations · Full text

Life Sciences, Genetics, Oncology +14

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

François Binet, Gaël Cagnone, Sergio Crespo‐Garcia et al. · Science · 2020 · 288 citations

Medicine, Immunology, Ophthalmology +17

Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition

Sergio Crespo‐Garcia, Pamela R. Tsuruda, Agnieszka Dejda et al. · Cell Metabolism · 2021 · 178 citations · Full text

Medicine, Cell Biology, Ophthalmology +17

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

William Lee, Jacqueline L. Johnson, Daniel J. Gough et al. · Cell Death and Disease · 2015 · 131 citations · Full text

Medicine, Genetics, Oncology +12

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

Georgia Zarkada, Joel P. Howard, Xue Xiao et al. · Developmental Cell · 2021 · 126 citations · Full text

Life Sciences, Cell Biology, Developmental Biology +13