Deepa Bhavsar

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury

Mariano Severgnini, Satoe Takahashi, Powen Tu et al. · American Journal of Respiratory and Critical Care Medicine · 2005 · 94 citations

Acute Lung Injury, Src Kinase, Inflammatory Lung Disease +19

Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase PI3Kα

Mariana Nacht, Lixin Qiao, Michael P. Sheets et al. · Journal of Medicinal Chemistry · 2013 · 85 citations · Full text

Drug Target, Chemical Biology, Cancer Biology +18

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

Kirsten McAulay, Emily Hoyt, Morgan Thomas et al. · Journal of the American Chemical Society · 2020 · 73 citations · Full text

Discovery of <i>N</i>-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1<i>H</i>-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

Jason G. Kettle, Rana Anjum, Evan Barry et al. · Journal of Medicinal Chemistry · 2018 · 60 citations · Full text

Tyrosine Kinase Pdgfrα, Pharmacotherapy, Pharmaceutical Chemistry +21

Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors

Erica Banks, Michael Grondine, Deepa Bhavsar et al. · Science Translational Medicine · 2020 · 26 citations