Leif M. Laakso

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Yonghan Hu, Jason Xiang, Martin DiGrandi et al. · Bioorganic & Medicinal Chemistry · 2005 · 107 citations

Medicine, Chronic Musculoskeletal Condition, Osteoarthritis +3

FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)–C(34) fragment of FK-506, FR-900520, and FR-900523

Amos B. Smith, Karl J. Hale, Leif M. Laakso et al. · Tetrahedron Letters · 1989 · 74 citations

Biochemistry, Natural Sciences, Molecular Biology +5

Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine

Edward J. Salaski, Girija Krishnamurthy, Weidong Ding et al. · Journal of Medicinal Chemistry · 2009 · 72 citations · Full text

Chemical Biology, Pharmaceutical Chemistry, Drug Resistance +16

Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates

Jeremy I. Levin, J.M. Chen, Leif M. Laakso et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 54 citations · Full text

Medicinal Chemistry, Medicine, Acetylenic Tace Inhibitors +5

Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates

Jeremy I. Levin, J.M. Chen, Leif M. Laakso et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 53 citations · Full text

Medicinal Chemistry, Natural Sciences, Acetylenic Tace Inhibitors +8