Bradley Sherborne

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Jun Lu, Noel Byrne, John Wang et al. · Nature Structural & Molecular Biology · 2017 · 194 citations

Signal Transduction, Molecular Physiology, Biochemistry +7

Molecular Simulations Identify Binding Poses and Approximate Affinities of Stapled α-Helical Peptides to MDM2 and MDMX

Joseph A. Morrone, Alberto Pérez, Qiaolin Deng et al. · Journal of Chemical Theory and Computation · 2017 · 62 citations

Engineering, Molecular Biology, Peptide Science +22

Collaborating to improve the use of free-energy and other quantitative methods in drug discovery

Bradley Sherborne, Veerabahu Shanmugasundaram, Alan C. Cheng et al. · Journal of Computer-Aided Molecular Design · 2016 · 59 citations

Drug Target, Other Quantitative Methods, Hit Identification +7

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology

Sobhana Babu Boga, Yongqi Deng, Liang Zhu et al. · ACS Medicinal Chemistry Letters · 2018 · 49 citations · Full text

Discovery of novel low molecular weight inhibitors of IMPDH via virtual needle screening

Stephen D. Pickett, Bradley Sherborne, Trevor Wilkinson et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 37 citations · Full text

Virtual Needle Screening, Medicinal Chemistry, Pharmaceutical Research +11