Jan Heeres

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Kalyan Das, Arthur D. Clark, Paul Lewi et al. · Journal of Medicinal Chemistry · 2004 · 511 citations

Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent

Jan Heeres, L. J. J. Backx, J. H. Mostmans et al. · Journal of Medicinal Chemistry · 1979 · 340 citations

TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Koen Andries, Hilde Azijn, Theo Thielemans et al. · Antimicrobial Agents and Chemotherapy · 2004 · 322 citations · Full text

Immunology, Pharmacotherapy, Antiviral Drug +17

Preparation and antimycotic properties of derivatives of 1-phenethylimidazole

Erik F. Godefroi, Jan Heeres, J. Van Cutsem et al. · Journal of Medicinal Chemistry · 1969 · 264 citations

SYNOPSIS:  SYNthesize and OPtimize System in Silico

H. Maarten Vinkers, Marc R. de Jonge, Frederik F. D. Daeyaert et al. · Journal of Medicinal Chemistry · 2003 · 227 citations

Combinatorial Chemistry, Engineering, Computer Architecture +19